📰 The molecular effects of caffeine on the brain

Scientists are unraveling the molecular mechanisms underlying caffeine’s effects on the brain. This work, carried out on mice and published in the journal The Journal of Clinical Research, reinforce the idea of ​​a beneficial effect of caffeine (Caffeine is an alkaloid of the methylxanthine family, present in many…) on cognitive functions.

Caffeine is the most consumed psychoactive substance in world (The word world can refer to:). While its effects on surveillance (Your attention takes on an aspect of intensity to call on all of your abilities to…) and attention are widely known, the brain molecular mechanisms associated with its regular consumption remained poorly understood until now.


Chronic treatment of mice with caffeine. induced (The armature is a generally electromagnetic device used in electrical engineering responsible for…) concerted epigenetic changes in neuronal and non-neuronal cells, underlying a decrease in metabolism (Metabolism is the set of molecular and energetic transformations…) (energetic and lipid) and an increase in genes and proteins involved in neuronal signaling and plasticity. This is followed by a fine-tuning of the metabolism (fine-tuning) and an increase in the ability of neurons to respond (priming) to a task oflearning (Learning is the acquisition of know-how, that is, the process…) space.
© I Paiva, AL Boutillier, D Blum, Biorender

Scientists show in mice that regular caffeine consumption induces long-lasting molecular changes in the hippocampus, a structure essential for memory (In general terms, memory is the storage of information. It is also remembering…) and that degenerates into illness (Disease is an alteration of the functions or health of a living organism, animal…) Alzheimer’s The results obtained by different methods combining genomics (Genomics is a discipline of modern biology. It studies how…), metabolomics and proteomics suggest that caffeine promotes information processing in this structure in response to a learning task, by exerting a concerted action on neuronal and non-neuronal cells. Caffeine significantly modifies the epigenome of the hippocampus in a manner differentiated according to whether they are neuronal or non-neuronal cells. This helps promote the molecular processes associated with memory.

This study provides evidence experimental (In art, these are creative approaches based on questioning dogmas…) of a link between caffeine consumption and neural processes involved in memory and encourages us to decipher more precisely the molecular effects of caffeine on different brain cells and to better understand the caffeine/memory link inmen (A man is an adult male individual of the species called Modern Man (Homo…). In particular, a possible beneficial effect in patients with Alzheimer’s disease is currently theobject (In general, the word object (from the Latin objectum, 1361) designates an entity defined in…) of’clinical trial (A clinical trial is a scientific study conducted in therapy…) CAFC (NCT04570085).

To know more:
Caffeine ingestion exerts dual genome-wide effects on hippocampal metabolism and transcription-dependent learning.
Paiva I, Cellai L, Meriaux C, Poncelet L, Nebie O, Saliou JM, Lacoste AS, Papegaey A, Drobecq H, Le Gras S, Schneider M, Malik EM, Müller CE, Faivre E, Carvalho K, Gomez-Murcia V , Vieau D, Thiroux B, Eddarkaoui S, Lebouvier T, Schueller E, Tzeplaeff L, Grgurina I, Seguin J, Stauber J, Lopes LV, Buée L, Buée-Scherrer V, Cunha RA, Ait-Belkacem R, Sergeant N, Annicotte JS, Boutillier AL, Blum D.
The Journal of Clinical Investigation May 10, 2022. https://doi.org/10.1172/JCI149371.

Laboratory:
– Lilac neuroscience (Neurosciences correspond to the set of all biological disciplines and…) and cognition. (University of Lille/Inserm). Lille University Hospital. street (The street is a circulation space in the city that serves homes and places…) Polonovsky, 59000 Lille.
– Laboratory of Cognitive and Adaptive Neurosciences (LNCA). CNRS/University of Strasbourg. Faculty of Psychology. Rue Goethe, 12. 67000 Strasbourg.

contacts:
-David Blum- Seeker (A researcher (fem. researcher) refers to a person whose job it is to investigate…) Inserm in Lille neuroscience and cognition – david.blum on inserm.fr
– Anne-Laurence Boutillier – Researcher CNRS (The National Center for Scientific Research, better known by its acronym CNRS, is the largest…) in the Laboratory of Cognitive and Adaptive Neurosciences. LNCA (CNRS/University of Strasbourg) – laurette on unistra.fr

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